Sleep and metabolism: shared circuits, new connections.

Adamantidis, Antoine Roger; de Lecea, Luis (2008). Sleep and metabolism: shared circuits, new connections. Trends in endocrinology and metabolism, 19(10), pp. 362-370. Elsevier Current Trends 10.1016/j.tem.2008.08.007

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Association between sleep disturbances and hormonal imbalances can result in metabolic disorders, including obesity and diabetes. The hypothalamus is likely to play a part in these pathophysiological conditions because it contains sleep-wake circuits that are sensitive to metabolic hormones, including leptin and ghrelin. Thus, shared hypothalamic circuits such as the hypocretin and melanin-concentrating hormone systems are strong candidates for mediating both sleep and metabolic imbalances. This review reveals new roles for these systems as sensors and effectors of sleep and wakefulness, and discusses their plasticity in regulating sleep and energy balance. New optical tools that remotely control neuronal circuit activity provide an effective means to understand the cooperativity of shared circuits in regulating hypothalamic functions such as sleep and metabolism.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1043-2760

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

11 Jul 2018 15:46

Last Modified:

03 Nov 2019 18:17

Publisher DOI:

10.1016/j.tem.2008.08.007

PubMed ID:

18938086

BORIS DOI:

10.7892/boris.117271

URI:

https://boris.unibe.ch/id/eprint/117271

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