Metastases in Prostate Cancer.

La Manna, Federico; Karkampouna, Sofia; Zoni, Eugenio; De Menna, Marta; Hensel, Janine; Thalmann, George; Kruithof-de Julio, Marianna (2019). Metastases in Prostate Cancer. Cold Spring Harbor perspectives in medicine, 9(3) Cold Spring Harbor Laboratory Press 10.1101/cshperspect.a033688

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Prostate cancer (PCa) prognosis and clinical outcome is directly dependent on metastatic occurrence. The bone microenvironment is a favorable metastatic niche. Different biological processes have been suggested to contribute to the osteotropism of PCa such as hemodynamics, bone-specific signaling interactions, and the "seed and soil" hypothesis. However, prevalence of disseminating tumor cells in the bone is not proportional to the actual occurrence of metastases, as not all patients will develop bone metastases. The fate and tumor-reforming ability of a metastatic cell is greatly influenced by the microenvironment. In this review, the molecular mechanisms of bone and soft-tissue metastasis in PCa are discussed. Specific attention is dedicated to the residual disease, novel approaches, and animal models used in oncological translational research are illustrated.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

La Manna, Federico; Karkampouna, Sofia; Zoni, Eugenio; De Menna, Marta; Thalmann, George and Kruithof-de Julio, Marianna

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2157-1422

Publisher:

Cold Spring Harbor Laboratory Press

Language:

English

Submitter:

Laetitia Hayoz

Date Deposited:

04 Jul 2018 10:02

Last Modified:

25 Oct 2019 03:39

Publisher DOI:

10.1101/cshperspect.a033688

Related URLs:

PubMed ID:

29661810

BORIS DOI:

10.7892/boris.118227

URI:

https://boris.unibe.ch/id/eprint/118227

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