Repeat prostate biopsies prior to radical prostatectomy do not impact erectile function recovery and mid- to long-term continence.

Furrer, Marc; Vilaseca, Antoni; Corradi, Renato B; Boxler, Silvan; Thalmann, George; Nguyen, Daniel P (2018). Repeat prostate biopsies prior to radical prostatectomy do not impact erectile function recovery and mid- to long-term continence. Prostate, 78(8), pp. 631-636. Wiley-Blackwell 10.1002/pros.23509

[img] Text
Furrer_et_al-2018-The_Prostate.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (427kB) | Request a copy


A growing number of men undergo repeat biopsies prior to radical prostatectomy for prostate cancer. However, the long-term impact of repeat biopsies on functional outcomes in this patient population remains unelucidated. Thus, we compared functional outcomes between patients who underwent single biopsy versus repeat biopsies before radical prostatectomy.


From 1996 to 2015, 1015 consecutive patients underwent radical prostatectomy, and subsequently had urinary continence and erectile function assessed for >2 years follow-up. One-fourth of patients (275; 27%) had ≥2 biopsies before prostatectomy. Logistic regression models tested whether repeat biopsy before prostatectomy predicted continence or erectile function recovery.


For the overall cohort, continence rates were 84%, 92%, 96%, and 98% at 3, 6, 12, and 24 months, respectively. Repeat biopsy before prostatectomy was associated with lower continence rate at 3 months compared to single biopsy (P = 0.03); however, no significant differences were observed at 6, 12, or 24 months. In multivariable analyses adjusting for age, body mass index and diabetes/cardiovascular disease/smoking, the association between repeat biopsy and lower likelihood of continence at 3 months remained (odds ratio 0.67, 95% confidence interval 0.47-0.97; P = 0.03). Overall erectile function recovery rates were 16%, 33%, 51%, and 55% at 3, 6, 12, and 24 months, respectively. No difference in erectile function recovery rates was seen at any time point for single biopsy versus repeat biopsy. In multivariable analyses, repeat biopsy was not predictive of erectile function recovery at any time point.


Repeat biopsy before radical prostatectomy impairs early continence after surgery. However, erectile function recovery and mid-term to long-term continence are not affected. These data support the current trend towards active surveillance and delayed local treatment in patients with low- to intermediate-risk prostate cancer.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Furrer, Marc, Boxler, Silvan, Thalmann, George, Nguyen, Daniel Truong Phat


600 Technology > 610 Medicine & health








Laetitia Hayoz

Date Deposited:

03 Jul 2018 11:46

Last Modified:

05 Dec 2022 15:16

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

biopsy erectile dysfunction prostate cancer prostatectomy urinary incontinence




Actions (login required)

Edit item Edit item
Provide Feedback