Todenhöfer, Tilman; Struss, Werner J; Seiler, Roland; Wyatt, Alexander William; Black, Peter C (2018). Liquid Biopsy-Analysis of Circulating Tumor DNA (ctDNA) in Bladder Cancer. Bladder cancer, 4(1), pp. 19-29. IOS Press 10.3233/BLC-170140
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Recent advances in DNA profiling techniques have enabled sensitive detection of tumor-associated genomic aberrations in peripheral blood. This type of minimally-invasive molecular interrogation has the potential to guide subsequent treatment selection. The potential utility of ctDNA in bladder cancer (BC) is bolstered by the high somatic mutation rate, meaning that very small numbers of genes or target regions can be informative. First reports indicate that analysis of ctDNA may represent a sensitive method for disease surveillance in patients with different stages of BC. Moreover, recent evidence suggests that ctDNA analysis reveals previously unknown genomic alterations in metastatic patients. Since some of these gene alterations represent therapeutic targets, ctDNA analysis provides an attractive tool to guide individualized therapy in BC.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology |
UniBE Contributor: |
Seiler-Blarer, Roland |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2352-3727 |
Publisher: |
IOS Press |
Language: |
English |
Submitter: |
Laetitia Hayoz |
Date Deposited: |
04 Jul 2018 15:29 |
Last Modified: |
02 Mar 2023 23:30 |
Publisher DOI: |
10.3233/BLC-170140 |
PubMed ID: |
29430504 |
Uncontrolled Keywords: |
Biomarker PCR blood cfDNA ctDNA next generation sequencing |
BORIS DOI: |
10.7892/boris.118242 |
URI: |
https://boris.unibe.ch/id/eprint/118242 |
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