Decompensated Heart Failure and Renal Failure: What Is the Current Evidence?

Bielecka-Dabrowa, Agata; Godoy, Breno; Schefold, Joerg C.; Koziolek, Michael; Banach, Maciej; von Haehling, Stephan (2018). Decompensated Heart Failure and Renal Failure: What Is the Current Evidence? Current heart failure reports, 15(4), pp. 224-238. Springer 10.1007/s11897-018-0397-5

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PURPOSE OF REVIEW Acute decompensated heart failure (ADHF) is one of the biggest challenges in the management of chronic heart failure. Despite several advances in medical and device therapy, high readmission and mortality rates continue to be a burden on healthcare systems worldwide. The aim of the current review is to provide an overview on current as well as future approaches in cardiorenal interactions in patients with ADHF. RECENT FINDINGS One of the strongest predictors of adverse outcomes in ADHF is renal dysfunction, referred to as cardiorenal syndromes (CRS) or cardiorenal interactions. Patients with ADHF frequently develop worsening of renal function (WRF) and/or acute kidney injury (AKI). Recent studies brought new information about biomarkers in diagnosing and predicting prognosis of CRS. Among others, dry weight at hospital discharge is considered a surrogate marker of successful treatment in ADHF patients with/without renal dysfunction. The etiology of WRF appears to be an important factor for determining risk related to WRF as well as clinical management. The hypertonic saline used as adjunctive therapy for intravenous loop diuretics and/or induction of aquaresis (e.g., using tolvaptan) may be promising and efficient approaches in the future.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Schefold, Joerg C.


600 Technology > 610 Medicine & health








Mirella Aeberhard

Date Deposited:

16 Jul 2018 07:43

Last Modified:

27 Oct 2019 12:51

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Acute decompensated heart failure Biomarkers Cardiorenal interactions Cardiorenal syndrome Hypertonic saline solution Tolvaptan




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