The Effect of Monitoring Viral Load and Tracing Patients Lost to Follow-up on the Course of the HIV Epidemic in Malawi: A Mathematical Model

Estill, Janne; Kerr, Cliff C; Blaser, Nello; Salazar-Vizcaya, Luisa; Tenthani, Lyson; Wilson, David P; Keiser, Olivia (2018). The Effect of Monitoring Viral Load and Tracing Patients Lost to Follow-up on the Course of the HIV Epidemic in Malawi: A Mathematical Model. Open Forum Infectious Diseases, 5(5), ofy092. Oxford University Press 10.1093/ofid/ofy092

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Background Antiretroviral therapy (ART) reduces HIV transmission, but treated patients may again become infectious. We used a mathematical model to determine whether ART as prevention is more effective if viral load (VL) is routinely monitored and patients lost to follow-up (LTFU) traced. Methods We simulated ART cohorts to parameterize a deterministic transmission model calibrated to Malawi. We investigated the following strategies for improving treatment and retention: monitoring VL every 12 or 24 months, tracing patients LTFU, or a generic strategy leading to uninterrupted treatment. We tested 3 scenarios, where ART scale-up continues at current (Universal ART), reduced (Failed scale-up), or accelerated speed (Test&Treat). Results In the Universal ART scenario, between 2017 and 2020 (2050), monitoring VL every 24 months prevented 0.5% (0.9%), monitoring every 12 months prevented 0.8% (1.4%), tracing prevented 0.3% (0.5%), and uninterrupted treatment prevented 5.5% (9.9%) of HIV infections. Failed scale-up resulted in 25% more infections than the Universal ART scenarios, whereas Test&Treat resulted in 7%-8% less. Conclusions Test&Treat reduces transmission of HIV, despite individual cases of treatment failure and ART interruption. Whereas viral load monitoring and tracing have only a minor impact on transmission, interventions that aim to minimize treatment interruptions can further increase the preventive effect of ART.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Mathematics and Statistics > Institute of Mathematical Statistics and Actuarial Science
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Estill, Janne Anton Markus; Blaser, Nello; Salazar Vizcaya, Luisa Paola; Tenthani, Lyson Nemoni and Keiser, Olivia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
500 Science > 510 Mathematics

ISSN:

2328-8957

Publisher:

Oxford University Press

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

28 Aug 2018 12:02

Last Modified:

23 Oct 2019 03:19

Publisher DOI:

10.1093/ofid/ofy092

PubMed ID:

29977952

Uncontrolled Keywords:

HIV; antiretroviral therapy; loss to follow-up; mathematical model; monitoring; transmission

BORIS DOI:

10.7892/boris.118550

URI:

https://boris.unibe.ch/id/eprint/118550

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