Striatal cerebral blood flow, executive functioning, and fronto-striatal functional connectivity in clinical high risk for psychosis

Hubl, Daniela; Schultze-Lutter, Frauke; Hauf, Martinus; Dierks, Thomas; Federspiel, Andrea; Kaess, Michael; Michel, Chantal; Schimmelmann, Benno Karl Edgar; Kindler, Jochen (2018). Striatal cerebral blood flow, executive functioning, and fronto-striatal functional connectivity in clinical high risk for psychosis. Schizophrenia Research, 201, pp. 231-236. Elsevier 10.1016/j.schres.2018.06.018

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BACKGROUND: Patients at clinical high risk (CHR) for psychosis exhibit increased striatal cerebral blood flow (CBF) during the resting state and impaired cognitive function. However, the relation between CBF and cognitive impairment is unknown. We therefore studied the association between striatal CBF and executive functioning and evaluated the functional connectivity (FC) between dorsal striatum and the frontal cortex in CHR. METHODS: In total, 47 participants [29 with CHR, 18 matched clinical controls (CC)] were assessed for ultra-high-risk criteria and basic symptoms and were tested for executive functioning using the trail making test-B (TMT-B). Resting state mean CBF and FC were calculated from arterial spin labeling 3T MRI data. RESULTS: Striatal CBF was highest in CHR patients with TMT-B deficits and was significantly higher than that in CC with and without TMT-B impairment. Further, a significantly lower CBF FC between the dorsal striatum and the anterior cingulate cortex was revealed in CHR. CONCLUSIONS: Our study suggests that higher striatal CBF might represent focal pathology in CHR and is associated with disrupted cingulo-striatal FC and executive dysfunctions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Hubl, Daniela; Schultze-Lutter, Frauke; Hauf, Martinus; Dierks, Thomas; Federspiel, Andrea; Kaess, Michael; Michel, Chantal; Schimmelmann, Benno Karl Edgar and Kindler, Jochen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0920-9964

Publisher:

Elsevier

Language:

English

Submitter:

Livia Hug

Date Deposited:

16 Jul 2018 13:02

Last Modified:

16 Jul 2019 08:09

Publisher DOI:

10.1016/j.schres.2018.06.018

PubMed ID:

29983268

Uncontrolled Keywords:

Anterior cingulate cortex, Arterial spin labeling, Cerebral blood flow, Cognition, Connectivity, Psychosis risk, Striatum

BORIS DOI:

10.7892/boris.118563

URI:

https://boris.unibe.ch/id/eprint/118563

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