Immunology of Alveolar and Cystic Echinococcosis (AE and CE).

Gottstein, Bruno; Soboslay, P; Ortona, E; Wang, Junhua; Siracusano, A; Vuitton, D Α (2017). Immunology of Alveolar and Cystic Echinococcosis (AE and CE). Advances in Parasitology, 96, pp. 1-54. Elsevier 10.1016/bs.apar.2016.09.005

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Cystic and alveolar echinococcosis are severe chronic helminthic diseases caused by the cystic growth or the intrahepatic tumour-like growth of the metacestode of Echinococcus granulosus or Echinococcus multilocularis, respectively. Both parasites have evolved sophisticated strategies to escape host immune responses, mainly by manipulating and directing this immune response towards anergy and/or tolerance. Recent research studies have revealed a number of respective immunoregulatory mechanisms related to macrophages and dendritic cell as well as T cell activities (regulatory T cells, Tregs). A better understanding of this complex parasite-host relationship, and the elucidation of specific crucial events that lead to disease, represents targets towards the development of novel treatment strategies and options.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Gottstein, Bruno and Wang, Junhua

Subjects:

600 Technology > 630 Agriculture
500 Science
600 Technology > 610 Medicine & health

ISSN:

2163-6079

Publisher:

Elsevier

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

18 Jul 2018 12:00

Last Modified:

18 Jul 2018 12:00

Publisher DOI:

10.1016/bs.apar.2016.09.005

PubMed ID:

28212788

Uncontrolled Keywords:

Alveolar echinococcosis Cystic echinococcosis Dendritic cells Fibrinogen-like protein 2 Macrophages Regulatory T cells TGF-β Vaccination

URI:

https://boris.unibe.ch/id/eprint/118622

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