Species-specific immunodiagnosis of Taenia solium cysticercosis by ELISA and immunoblotting.

Gottstein, Bruno; Zini, D; Schantz, P M (1987). Species-specific immunodiagnosis of Taenia solium cysticercosis by ELISA and immunoblotting. Tropical medicine and parasitology, 38(4), pp. 299-303. Georg Thieme

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A combination of ELISA and immunoblotting was evaluated for immunodiagnosis of human T. solium cysticercosis. The sensitivity of ELISA for diagnosis of European, Latin-American, Asian and South African patients with cysticercosis was 75% for serum and 55% for cerebrospinal fluid specimen. Antigens originating from cysticerci in pigs from Mexico and South Africa were of adequate applicability. A species-specific confirmation of T. solium cysticercosis by immunoblotting (detection of antibody activity to the 26 K and 8 K bands) was achieved in 92% (serum) and 100% (CSF) of samples positive in ELISA. No antibodies from 147 patients with other helminth infections reacted with the 26 K and the 8 K band in immunoblotting, resulting in a specificity of 100%.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Gottstein, Bruno

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0177-2392

Publisher:

Georg Thieme

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

19 Jul 2018 09:28

Last Modified:

19 Jul 2018 09:28

PubMed ID:

3441736

URI:

https://boris.unibe.ch/id/eprint/118627

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