Em2-ELISA for the follow-up of alveolar echinococcosis after complete surgical resection of liver lesions.

Gottstein, Bruno; Tschudi, K; Eckert, J; Ammann, R (1989). Em2-ELISA for the follow-up of alveolar echinococcosis after complete surgical resection of liver lesions. Transactions of the Royal Society of Tropical Medicine and Hygiene, 83(3), pp. 389-393. Royal Society of Tropical Medicine and Hygiene

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Alveolar echinococcosis, a serious and often fatal human disease, can be efficiently cured only by complete surgical resection of the Echinococcus multilocularis lesion. The present study showed that the determination in patients who had undergone surgery of antibody activity directed against the antigen Em2 reliably reflected complete or incomplete surgical resection. From 9 patients with pre-operative positive results in the Em2 enzyme-linked immunosorbent assay (Em2-ELISA) and successful surgical resection, 6 converted to negative within one year and the remaining 3 patients within 4 years after surgery. Six of 7 additional patients who showed recurrences in an average of 6 years after surgery despite assumed complete surgical resection, were positive by Em2-ELISA at the time of recurrence. Discrimination was not possible between these 2 groups of patients when using an ELISA employing crude antigen obtained from E. granulosus hydatid cyst fluid.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Gottstein, Bruno

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0035-9203

Publisher:

Royal Society of Tropical Medicine and Hygiene

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

23 Jul 2018 11:12

Last Modified:

23 Jul 2018 11:12

PubMed ID:

2617587

URI:

https://boris.unibe.ch/id/eprint/118639

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