Protective immune mechanisms against the metacestode of Echinococcus multilocularis.

Gottstein, Bruno; Felleisen, R (1995). Protective immune mechanisms against the metacestode of Echinococcus multilocularis. Parasitology today, 11(9), pp. 320-326. Elsevier 10.1016/0169-4758(95)80184-7

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Infection with the larval stage of the fox tapeworm Echinococcus multilocularis results in a life-threatening hepatic disease concerning humans and intermediate rodent hosts. Immunoepidemiological surveys provided information that a large proportion of infected individuals may demonstrate either constitutional resistance to early post-oncospheral development of the parasite or late resistance to disease by exhibiting an intrahepatic died-out parasite lesion. Similar events have been found in secondary infections of laboratory rodents. Dissection of humoral and cell-mediated immune responses in susceptible versus resistant individuals provides insight into immunological pathways associated with the different outcome of infection. Survival strategy of the metacestode obviously focuses on the crucial role played by the parasite laminated layer. This layer protects the metacestode from host effector mechanisms which can potentially kill the proliferating germinative compartments in case of resistant hosts. Bruno Gottstein and Richard Felleisen here discuss the need to search for more parameters discriminating between the different immune pathways in order to find out (immunogenetic?) predispositions responsible for the respective phenomena.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Gottstein, Bruno

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0169-4758

Publisher:

Elsevier

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

18 Jul 2018 15:53

Last Modified:

18 Jul 2018 16:25

Publisher DOI:

10.1016/0169-4758(95)80184-7

PubMed ID:

15275313

BORIS DOI:

10.7892/boris.118694

URI:

https://boris.unibe.ch/id/eprint/118694

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