Selection, recombination and history in a parasitic flatworm (Echinococcus) inferred from nucleotide sequences.

Haag, K L; Araújo, A M; Gottstein, Bruno; Zaha, A (1997). Selection, recombination and history in a parasitic flatworm (Echinococcus) inferred from nucleotide sequences. Memorias do Instituto Oswaldo Cruz, 93(5), pp. 695-702. Instituto Oswaldo Cruz, Ministério da Saúde, Rio de Janeiro, Brazil

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Three species of flatworms from the genus Echinococcus (E. granulosus, E. multilocularis and E. vogeli) and four strains of E. granulosus (cattle, horse, pig and sheep strains) were analysed by the PCR-SSCP method followed by sequencing, using as targets two non-coding and two coding (one nuclear and one mitochondrial) genomic regions. The sequencing data was used to evaluate hypothesis about the parasite breeding system and the causes of genetic diversification. The calculated recombination parameters suggested that cross-fertilisation was rare in the history of the group. However, the relative rates of substitution in the coding sequences showed that positive selection (instead of purifying selection) drove the evolution of an elastase and neutrophil chemotaxis inhibitor gene (AgB/1). The phylogenetic analyses revealed several ambiguities, indicating that the taxonomic status of the E. granulosus horse strain should be revised.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Gottstein, Bruno

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0074-0276

Publisher:

Instituto Oswaldo Cruz, Ministério da Saúde, Rio de Janeiro, Brazil

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

23 Jul 2018 12:51

Last Modified:

23 Jul 2018 12:51

PubMed ID:

9830541

URI:

https://boris.unibe.ch/id/eprint/118740

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