Weight gain of HIV-exposed, uninfected children born before and after introduction of the "Option B+" programme in Malawi.

Msukwa, Malango T; Estill, Janne; Haas, Andreas D; van Oosterhout, Joep J; Tenthani, Lyson; Davies, Mary-Ann; Tal, Kali; Phiri, Nozgechi; Spörri, Adrian; Mthiko, Bryan C; Chimbwandira, Frank; Keiser, Olivia (2018). Weight gain of HIV-exposed, uninfected children born before and after introduction of the "Option B+" programme in Malawi. AIDS, 32(15), pp. 2201-2208. Lippincott Williams & Wilkins 10.1097/QAD.0000000000001942

Msukwa AIDS 2018_manuscript.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (230kB) | Preview
[img] Text
Msukwa AIDS 2018.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (190kB) | Request a copy

OBJECTIVE To compare birth weight and weight gain in HIV-exposed, uninfected infants up to 24 months old, who enrolled in the Malawian national HIV care clinic (HCC) programme either before or after Option B+ (OB+) was implemented. DESIGN, SETTING AND PARTICIPANTS HIV-exposed infants enrol in the HCC programme as soon as possible after birth and are followed up to at least 24 months old. This analysis includes HIV-exposed, uninfected (HEU) infants with recorded birth weight, date of birth, gender and at least one follow-up weight measurement from 21 health facilities in central and southern Malawi (January 2010 - December 2014). Weight-for-age z-scores (WAZ) were derived and compared by birth period using linear regression at birth and mixed effects models for postnatal weight gain up to 24 months old. RESULTS Of 6,845 HEU infants included in this study, 88.5% were born after OB+. The proportion of infants exposed in-utero to combination antiretroviral therapy (ART) significantly increased after OB+ was implemented, and infants were exposed to ART for a longer time. There was no significant difference in WAZ at birth (p = 0.654) among HEU infants by birth period, but postnatal weight gain was faster among HEU infants born in the Option B+ period than infants born pre-Option B+. CONCLUSION Birth weight was not affected by longer exposure to ART during pregnancy after OB+ was introduced, when weight gain in HEU infants was faster, possibly because their mothers were in better health.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
08 Faculty of Science > Department of Mathematics and Statistics > Institute of Mathematical Statistics and Actuarial Science

UniBE Contributor:

Estill, Janne Anton Markus; Haas, Andreas; Tal, Kali and Spörri, Adrian


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
500 Science > 510 Mathematics




Lippincott Williams & Wilkins




Tanya Karrer

Date Deposited:

19 Jul 2018 14:15

Last Modified:

24 Oct 2019 14:18

Publisher DOI:


PubMed ID:






Actions (login required)

Edit item Edit item
Provide Feedback