Culture of Echinococcus multilocularis metacestodes: an alternative to animal use.

Hemphill, Andrew; Stettler, Marianne; Walker, Mirjam; Siles-Lucas, Mar; Fink, Renate; Gottstein, Bruno (2002). Culture of Echinococcus multilocularis metacestodes: an alternative to animal use. Trends in parasitology, 18(10), pp. 445-451. Elsevier Current Trends

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This article reviews the use of an in vitro culture model for the maintenance and proliferation of Echinococcus multilocularis metacestodes and the formation of protoscoleces. This model has been used to identify and characterize parasite molecules involved in host-parasite interactions, and is a suitable tool to perform in vitro drug-screening assays. The development of a simple and easy-to-handle assay to determine the effects of drugs on parasite viability, without the need for time-consuming animal experimentation, has opened the way for larger-scale in vitro drug screening.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Hemphill, Andrew and Gottstein, Bruno

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

1471-4922

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

23 Jul 2018 11:15

Last Modified:

23 Jul 2018 11:15

PubMed ID:

12377595

URI:

https://boris.unibe.ch/id/eprint/118827

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