Current trends in tissue-affecting helminths.

Gottstein, Bruno; Piarroux, R (2008). Current trends in tissue-affecting helminths. Parasite : journal de la Société Française de Parasitologie, 15(3), pp. 291-298. PDG Communication 10.1051/parasite/2008153291

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Some helminths have by their evolution learnt to systemically invade a host organism, and to select specific organs or host cell types as predilection site to reside, maturate or even proliferate. These parasites needed to develop complex and unique strategies to escape host immune reactions. The present work sheds some light into the strategy developed by three different helminths (Echinococcus multilocularis, Trichinella spiralis and Toxocara conis) to survive in the host organ or host cell, respectively. The crucial role of periparasitic host reactions that may help the host to control the parasite, but which may also be responsible for immunopathological events harmful to the host himself, are elucidated as well. Finally, for these three parasites selected, the murine host appears an acceptable model for carrying out experimental studies, as for these parasites, rodents as well as humans become infected in the parasites natural life cycle. Therefore, conclusions drawn from murine experiments may provide much more reliable data in view of their relevance for the human infection, a fact that frequently lacks when using mice as experimental model for other helminths.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Gottstein, Bruno

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

1252-607X

Publisher:

PDG Communication

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

23 Jul 2018 14:52

Last Modified:

23 Jul 2018 14:52

Publisher DOI:

10.1051/parasite/2008153291

PubMed ID:

18814697

BORIS DOI:

10.7892/boris.118881

URI:

https://boris.unibe.ch/id/eprint/118881

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