High genetic structuring of Tula hantavirus

Schmidt, Sabrina; Saxenhofer, Moritz; Drewes, Stephan; Schlegel, Mathias; Wanka, Konrad M.; Frank, Raphael; Klimpel, Sven; von Blanckenhagen, Felix; Maaz, Denny; Herden, Christiane; Freise, Jona; Wolf, Ronny; Stubbe, Michael; Borkenhagen, Peter; Ansorge, Hermann; Eccard, Jana A.; Lang, Johannes; Jourdain, Elsa; Jacob, Jens; Marianneau, Philippe; ... (2016). High genetic structuring of Tula hantavirus. Archives of virology, 161(5), pp. 1135-1149. Springer 10.1007/s00705-016-2762-6

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Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT-PCR and TULV-IgG ELISA. TULV-specific RNA and/or antibodies were detected at 43 of the sites, demonstrating a geographically widespread distribution of the virus in the studied area. The TULV prevalence in common voles (16.7 %) was higher than that in field voles (9.2 %) and water voles (10.0 %). Time series data at ten trapping sites showed evidence of a lasting presence of TULV RNA within common vole populations for up to 34 months, although usually at low prevalence. Phylogenetic analysis demonstrated a strong genetic structuring of TULV sequences according to geography and independent of the rodent species, confirming the common vole as the preferential host, with spillover infections to co-occurring field and water voles. TULV phylogenetic clades showed a general association with evolutionary lineages in the common vole as assessed by mitochondrial DNA sequences on a large geographical scale, but with local-scale discrepancies in the contact areas.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE)

UniBE Contributor:

Saxenhofer, Moritz and Heckel, Gerald

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0304-8608

Publisher:

Springer

Language:

English

Submitter:

Susanne Holenstein

Date Deposited:

24 Jul 2018 15:47

Last Modified:

24 Jul 2018 15:47

Publisher DOI:

10.1007/s00705-016-2762-6

BORIS DOI:

10.7892/boris.118940

URI:

https://boris.unibe.ch/id/eprint/118940

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