High-Resolution Ion Mobility Spectrometry for Rapid Cannabis Potency Testing.

Hädener, Marianne; Kamrath, Michael Z; Weinmann, Wolfgang; Groessl, Michael (2018). High-Resolution Ion Mobility Spectrometry for Rapid Cannabis Potency Testing. Analytical chemistry, 90(15), pp. 8764-8768. American Chemical Society 10.1021/acs.analchem.8b02180

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We report initial results from an ion mobility spectrometry (IMS)-based analysis of natural cannabis samples and explore the possibility of using this technique to distinguish medical marijuana from illegal forms of the drug, as defined by Swiss legislation. We analyzed cannabis extracts by electrospray ionization IMS-MS and found that high-resolution drift-tube IMS ( R > 150) can effectively isolate and quantify the controlled substance, Δ9-tetrahydrocannabinol (THC), even in the presence of other noncontrolled cannabinoid isomers including cannabidiol (CBD). We used this information to determine whether the THC content of a given sample surpassed the legal limit, which is 1% by weight in Switzerland. Our IMS-MS methodology produced equivalent quantification results to standard HPLC-based methods and offers the additional advantage of significantly shorter time requirements for the analysis. In addition, IMS-based analysis offers flexibility over HPLC in that it can be performed on portable devices. As such, these findings may have implications for cannabis testing in police laboratories.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Management
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Hädener, Marianne; Weinmann, Wolfgang and Groessl, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0003-2700

Publisher:

American Chemical Society

Language:

English

Submitter:

Antoinette Angehrn

Date Deposited:

31 Jul 2018 14:23

Last Modified:

28 Oct 2019 00:03

Publisher DOI:

10.1021/acs.analchem.8b02180

PubMed ID:

29943977

BORIS DOI:

10.7892/boris.119007

URI:

https://boris.unibe.ch/id/eprint/119007

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