Novel targeted drug delivery systems to minimize systemic immunosuppression in vascularized composite allotransplantation.

Taddeo, Adriano; Tsai, Catherine; Vögelin, Esther; Rieben, Robert (2018). Novel targeted drug delivery systems to minimize systemic immunosuppression in vascularized composite allotransplantation. Current opinion in organ transplantation, 23(5), pp. 568-576. Lippincott Williams & Wilkins 10.1097/MOT.0000000000000564

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PURPOSE OF REVIEW The long-term adverse effects of immunosuppressive treatment, the high rate of acute rejection and the development of chronic rejection are the main factors preventing a wider clinical application of vascularized composite allotransplantation (VCA). Targeted immunosuppression using innovative drug delivery systems (DDS) may help to overcome these hurdles, increasing therapeutic efficacy while reducing systemic toxicity. This review provides a summary of the recently developed strategies for targeted delivery of immunosuppressive drugs in VCA. RECENT FINDINGS Currently, several innovative strategies for targeted immunosuppression have been designed based on the anatomy and function of the target organ. Site-specific DDS have been developed both for directly accessible organs (i.e. skin, eye and lung) and internal organs (i.e. lymph nodes, liver, nervous system, etc.). In preclinical models, DDS designed for sustained, 'on demand,' or 'on cue' drug release has been shown to promote VCA survival while reducing systemic toxicity. These findings suggest that targeted delivery could increase patient compliance and potentially decrease toxicity in VCA recipients. SUMMARY Targeted immunosuppression in VCA represents a promising approach for improving patient compliance and graft survival while reducing off-target toxicity, intensity and frequency of acute rejection episodes and risk of chronic rejection. VIDEO ABSTRACT.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Hand Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Handchirurgie
09 Interdisciplinary Units > Microscopy Imaging Center MIC

UniBE Contributor:

Taddeo, Adriano; Tsai, Catherine; Vögelin, Esther and Rieben, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1087-2418

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Veronika Picha

Date Deposited:

06 Aug 2018 16:17

Last Modified:

02 Aug 2019 02:30

Publisher DOI:

10.1097/MOT.0000000000000564

PubMed ID:

30074507

BORIS DOI:

10.7892/boris.119079

URI:

https://boris.unibe.ch/id/eprint/119079

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