Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review.

Künzli, Andrea Brigitte; Marschall, Jonas; Schefold, Joerg C.; Schafer, Margaret; Engler, Oliver B; Ackermann-Gäumann, Rahel; Reineke, David C; Suter, Franziska Marta; Staehelin, Cornelia (2018). Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review. Clinical infectious diseases, 67(11), pp. 1788-1795. Oxford Univ. Press 10.1093/cid/ciy443

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Two travellers returning from South America were diagnosed with Andes hantavirus infection, the only member of the Hantaviridae family known to be transmitted from person to person. We describe the clinical course and therapeutic and infection control measures. While both patients showed high viral load (VL) and shedding over several months, 1 patient recovered within 1 week from severe respiratory illness that required noninvasive ventilation, whereas the second patient developed severe hantavirus cardiopulmonary syndrome that required extracorporeal membrane oxygenation for 27 days. The clinical course in the latter patient was complicated by severe disseminated intravascular coagulopathy with diffuse hemorrhage that necessitated mass transfusions, as well as by multiple organ failure, including the need for renal replacement therapy. Results of VL in blood, respiratory secretions, and semen for the first 9 months of follow-up are reported. To our knowledge, these are the first cases of Andes hantavirus infection detected in Europe.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Künzli, Andrea Brigitte; Marschall, Jonas; Schefold, Joerg C.; Schafer, Margaret; Suter, Franziska Marta and Staehelin, Cornelia

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1058-4838

Publisher:

Oxford Univ. Press

Language:

English

Submitter:

Mirella Aeberhard

Date Deposited:

10 Aug 2018 08:12

Last Modified:

15 Nov 2018 01:31

Publisher DOI:

10.1093/cid/ciy443

PubMed ID:

30084955

BORIS DOI:

10.7892/boris.119169

URI:

https://boris.unibe.ch/id/eprint/119169

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