Whole genome SNP analysis of bovine B. anthracis strains from Switzerland reflects strict regional separation of Simmental and Swiss Brown breeds in the past.

Derzelle, Sylviane; Aguilar Bultet, Lisandra; Frey, Joachim (2016). Whole genome SNP analysis of bovine B. anthracis strains from Switzerland reflects strict regional separation of Simmental and Swiss Brown breeds in the past. Veterinary microbiology, 196, pp. 1-8. Elsevier 10.1016/j.vetmic.2016.10.014

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Bacillus anthracis is an evolutionarily young species that presents an extremely low genetic diversity due to its slow mode of propagation, determined by short replication phases and long sporulation periods. In our ongoing efforts to elucidate phylogenetic relationships between European B. anthracis isolates, the genomes of five strains from Switzerland belonging to lineages B.Br.CNEVA and A.Br.Aust94 were sequenced. Comparative analysis with additional, available genomes from both lineages, were used to reconstruct the substructure of these populations. Genome-wide single-nucleotide polymorphism analysis revealed two phylogeographical different groups among the Swiss B.Br.CNEVA strains (central and eastern Switzerland), that define the oldest most recent common ancestor of the B.Br.CNEVA lineage currently known. Age-old practices of livestock selection, breeding and preservation of unique traits of local breeds in Alpine valleys have likely favored differentiation of regional B. anthracis populations over centuries and the emergence of genetically distinct strains in an otherwise similar environment.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Aguilar Bultet, Lisandra and Frey, Joachim

Subjects:

600 Technology > 630 Agriculture

ISSN:

0378-1135

Publisher:

Elsevier

Language:

English

Submitter:

Monika Mumenthaler

Date Deposited:

21 Aug 2018 13:00

Last Modified:

21 Aug 2018 13:10

Publisher DOI:

10.1016/j.vetmic.2016.10.014

PubMed ID:

27939145

Uncontrolled Keywords:

Bacillus anthracis Comparative genomics Molecular typing Single nucleotide polymorphism Whole genome sequencing

BORIS DOI:

10.7892/boris.119375

URI:

https://boris.unibe.ch/id/eprint/119375

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