Platelet Transfusion Induces Alloimmunization to D and Non-D Rhesus Antigens.

Reckhaus, Johanna; Jutzi, Markus; Fontana, Stefano; Bacher, Vera Ulrike; Vogt, Marco; Daskalakis, Michael; Mansouri Taleghani, Behrouz (2018). Platelet Transfusion Induces Alloimmunization to D and Non-D Rhesus Antigens. Transfusion medicine and hemotherapy, 45(3), pp. 167-172. Karger 10.1159/000490122

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Background Platelet concentrates (PC) contain residual contaminating red blood cells (RBC), being higher in pooled buffy coat PC (BC-PC) than in apheresis units (AP-PC). Data about PC-induced alloimmunization against non-D Rhesus (Rh) antigens are limited. Methods For all newly detected RhD and non-D alloantibodies between August 2015 and September /2017 we prospectively evaluated if they were triggered through PC by analyzing for incompatible RBC and/or PC transfusions. Results We found 5,799 positive results in 89,190 antibody screening tests. We identified 13 newly detectable Rh antibodies through incompatible PCs in 11 patients: 6× anti-D, 4× anti-E, 2× anti-c, 1× anti-f. They received a total of 156 PC (83 BC-PC; 73 AP-PC): 5 patients received incompatible BC-PC only, 1 patient received incompatible AP-PC only, 5 patients received incompatible BC-PC and AP-PC. Quality control showed a mean (range) of 0.304 (0.152-1.662) and 0.014 (0.003-0.080) × 10 RBC/l for BC-PC and AP-PC, respectively. Ten of the 11 patients received RBC transfusions, all of them being antigen-negative for the alloantibodies identified. Conclusions PC transfusions may not only induce RhD alloimmunization, but also immunization against further Rh antigens such as c, E, and f. The risk seems higher for BC-PC than for AP-PC. The results may have impact on future recommendations of PC transfusion with respect to Rh compatibility and upper limits of RBC contamination.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Fontana, Stefano; Bacher, Vera Ulrike; Daskalakis, Michael and Mansouri Taleghani, Behrouz


600 Technology > 610 Medicine & health








Pierrette Durand Lüthi

Date Deposited:

21 Aug 2018 11:46

Last Modified:

23 Oct 2019 04:34

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Hemovigilance Platelet transfusion Rhesus alloimmunization




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