Schreiber, Peter W; Bischoff-Ferrari, Heike A; Boggian, Katia; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J (2019). Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study. Transplant international, 32(1), pp. 49-58. Wiley-Blackwell 10.1111/tri.13328
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MAIN PROBLEM
Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency (25-OH vitamin D [25-OHD] < 50nmol/l) and no deficiency (25-OHD ≥ 50nmol/l) in incident infections after liver transplantation.
METHODS
In 135 liver transplant recipients blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the STCS database. Poisson regression was applied to address associations between vitamin D status and incident infections.
RESULTS
Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant (IRR 1.52, 95% CI 1.08-2.15, P=0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P=0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders.
CONCLUSIONS
Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections. This article is protected by copyright. All rights reserved.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Hirzel, Cédric |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0934-0874 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
29 Aug 2018 09:58 |
Last Modified: |
05 Dec 2022 15:17 |
Publisher DOI: |
10.1111/tri.13328 |
PubMed ID: |
30099788 |
Uncontrolled Keywords: |
infections liver transplantation post-transplant care vitamin D |
BORIS DOI: |
10.7892/boris.119433 |
URI: |
https://boris.unibe.ch/id/eprint/119433 |
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