Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study.

Schreiber, Peter W; Bischoff-Ferrari, Heike A; Boggian, Katia; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J (2019). Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study. Transplant international, 32(1), pp. 49-58. Wiley-Blackwell 10.1111/tri.13328

[img]
Preview
Text
Schreiber_et_al-2018-Transplant_International.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (472kB) | Preview

MAIN PROBLEM Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency (25-OH vitamin D [25-OHD] < 50nmol/l) and no deficiency (25-OHD ≥ 50nmol/l) in incident infections after liver transplantation. METHODS In 135 liver transplant recipients blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the STCS database. Poisson regression was applied to address associations between vitamin D status and incident infections. RESULTS Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant (IRR 1.52, 95% CI 1.08-2.15, P=0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P=0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders. CONCLUSIONS Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Hirzel, Cédric

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0934-0874

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

29 Aug 2018 09:58

Last Modified:

23 Oct 2019 06:42

Publisher DOI:

10.1111/tri.13328

PubMed ID:

30099788

Uncontrolled Keywords:

infections liver transplantation post-transplant care vitamin D

BORIS DOI:

10.7892/boris.119433

URI:

https://boris.unibe.ch/id/eprint/119433

Actions (login required)

Edit item Edit item
Provide Feedback