The Problem of High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms: Well-Differentiated Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Beyond.

Sorbye, Halfdan; Baudin, Eric; Perren, Aurel (2018). The Problem of High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms: Well-Differentiated Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Beyond. Endocrinology and metabolism clinics of North America, 47(3), pp. 683-698. Elsevier 10.1016/j.ecl.2018.05.001

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High-grade gastroenteropancreatic neuroendocrine neoplasms are well-differentiated neuroendocrine tumors or poorly differentiated small/large cell neuroendocrine carcinoma. Distinguishing these entities relies on different genetic backgrounds and resulting different biology. The new classification creates several problems. Almost all clinical treatment data on neuroendocrine neoplasms do not stratify between well and poorly differentiated, providing insufficient help in treatment selection. Treatment of gastroenteropancreatic neuroendocrine neoplasms should separate between well-differentiated neuroendocrine tumors and neuroendocrine carcinoma, and depends on primary tumor site, stage, proliferation rate, and clinical course. This article addresses how to diagnose and treat gastroenteropancreatic neuroendocrine neoplasms, focusing on well-differentiated neuroendocrine tumors versus neuroendocrine carcinomas.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Perren, Aurel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0889-8529

Publisher:

Elsevier

Language:

English

Submitter:

Aurel Perren

Date Deposited:

30 Aug 2018 10:00

Last Modified:

30 Aug 2018 10:00

Publisher DOI:

10.1016/j.ecl.2018.05.001

PubMed ID:

30098724

Uncontrolled Keywords:

Carcinoma Digestive Gastroenteropancreatic NEC NET G3 Neoplasms Neuroendocrine

URI:

https://boris.unibe.ch/id/eprint/119684

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