Reasons for Reperfusion Failures in Stent-Retriever-Based Thrombectomy: Registry Analysis and Proposal of a Classification System.

Kaesmacher, Johannes; Gralla, Jan; Mosimann, Pascal John; Zibold, Felix; Heldner, Mirjam Rachel; Piechowiak, Eike Immo; Dobrocky, Tomas; Arnold, Marcel; Fischer, Urs; Mordasini, Pasquale (2018). Reasons for Reperfusion Failures in Stent-Retriever-Based Thrombectomy: Registry Analysis and Proposal of a Classification System. AJNR. American journal of neuroradiology, 39(10), pp. 1848-1853. American Society of Neuroradiology 10.3174/ajnr.A5759

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In 5%-10% of patients with acute ischemic stroke with an intention to treat with mechanical thrombectomy, no reperfusion can be achieved (Thrombolysis in Cerebral Infarction score = 0/1). Purpose of this analysis was a systematic assessment of underlying reasons for reperfusion failures.


An intention-to-treat single-center cohort ( = 592) was re-evaluated for all patients in whom no reperfusion could be achieved ( = 63). Baseline characteristics of patients were compared between patients with and without reperfusion failures. After qualitative review of all cases with reperfusion failures, a classification system was proposed and relative frequencies were reported. In a second step, occurrence of delayed recanalization at 24 hours after reperfusion failure and dependency on IV-tPA were evaluated.


In 63/592 patients with an intention to perform stent-retriever thrombectomy, no reperfusion was achieved (TICI 0/1, 10.6%, 95% CI, 8.2%-13.1%). Older patients (adjusted OR per yr = 1.03; 95% CI, 1.01-1.05) and patients with M2 occlusion (adjusted OR = 3.36; 95% CI, 1.82-6.21) were at higher risk for reperfusion failure. In most cases, no reperfusion was a consequence of technical difficulties (56/63, 88.9%). In one-third of these cases, reperfusion failures were due to the inability to reach the target occlusion (20/63, 31.7%), while "stent-retriever failure" occurred in 39.7% (25/63) of patients. Delayed recanalization was very rare (18.2%), without dependence on IV-tPA pretreatment status.


Reasons for reperfusion failure in stent-retriever thrombectomy are heterogeneous. The failure to establish intracranial or cervical access is almost as common as stent-retriever failure after establishing intracranial access. Systematic reporting standards of reasons may help to further estimate relative frequencies and thereby guide priorities for technical development and scientific effort.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Kaesmacher, Johannes, Gralla, Jan, Mosimann, Pascal John, Zibold, Felix, Heldner, Mirjam Rachel, Piechowiak, Eike Immo, Dobrocky, Tomas, Arnold, Marcel, Fischer, Urs Martin, Mordasini, Pasquale Ranato


600 Technology > 610 Medicine & health




American Society of Neuroradiology




Martin Zbinden

Date Deposited:

07 Sep 2018 12:05

Last Modified:

02 Mar 2023 23:31

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