Does infection with Chlamydia trachomatis induce long-lasting partial immunity? Insights from mathematical modelling.

Omori, Ryosuke; Chemaitelly, Hiam; Althaus, Christian L; Abu-Raddad, Laith J (2019). Does infection with Chlamydia trachomatis induce long-lasting partial immunity? Insights from mathematical modelling. Sexually transmitted infections, 95(2), pp. 115-121. BMJ Publishing Group 10.1136/sextrans-2018-053543

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OBJECTIVES To explore whether existence of long-lasting partial immunity against reinfection with is necessary to explain prevalence patterns by age and sexual risk, and to provide a plausible estimate for the effect size, defined here as a reduction in susceptibility to reinfection. METHODS A population-based mathematical model was constructed to describe natural history and transmission dynamics by age and sexual risk. The model was parameterised using natural history, and epidemiological and sexual behaviour data, and applied for UK and US data. Sensitivity analyses were conducted to assess the robustness of predictions to variations in model structure and to examine the impact of alternative assumptions for the mechanism underlying partial immunity. RESULTS Partial immunity against reinfection was found necessary to explain observed prevalence patterns by age and sexual risk. The reduction in susceptibility to reinfection was estimated at 93% using UK data (95% uncertainty interval (UI)=88%-97%) and at 67% using US data (95% UI=24%-88%). The model-structure sensitivity analyses affirmed model predictions. The immunity-mechanism sensitivity analyses suggested a mechanism of susceptibility reduction against reinfection or a mechanism of infectious-period duration reduction upon reinfection. CONCLUSIONS A strong long-lasting partial immunity against reinfection should be present to explain observed prevalence patterns. The mechanism of immunity could be either a reduction in susceptibility to reinfection or a reduction in duration of infection on reinfection. infection appears to naturally elicit a strong long-lasting immune response, supporting the concept of vaccine development.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Althaus, Christian

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1368-4973

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

13 Sep 2018 11:54

Last Modified:

28 Feb 2019 01:31

Publisher DOI:

10.1136/sextrans-2018-053543

PubMed ID:

30181327

Uncontrolled Keywords:

epidemiology immunity mathematical model. prevalence reinfection sexually transmitted infection

BORIS DOI:

10.7892/boris.119944

URI:

https://boris.unibe.ch/id/eprint/119944

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