Bileck, Andrea; Flück Pandey, Christa Emma; Dhayat, Nasser; Grössl, Michael (2019). How high-resolution techniques enable reliable steroid identification and quantification. Journal of steroid biochemistry and molecular biology, 186, pp. 74-78. Elsevier 10.1016/j.jsbmb.2018.09.018
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Due to possible matrix interferences and artefact generation during sample preparation, careful method validation is required for quantitative bioanalytical methods, especially for analytes that are only present in low concentrations.
Using the identification and quantification of progesterone metabolite in the urine of newborns as an example, we show how modern high-resolution instruments can be used to verify analyte assignment and avoid pitfalls commonly encountered by the use of low-resolution instruments.
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