Giant cell glioblastoma in the cerebrum of a pembroke welsh corgi

Giri, D.K.; Aloisio, F.; Ajithdoss, D.K.; Ambrus, A.; Lidbury, J.A.; Hein, H.E.; Porter, B.F. (2011). Giant cell glioblastoma in the cerebrum of a pembroke welsh corgi. Journal of comparative pathology, 144(4), pp. 324-7. London: Elsevier 10.1016/j.jcpa.2010.10.008

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A 6-year-old, neutered female Pembroke Welsh corgi was presented with a 1-month history of ataxia and panting. The clinical signs progressed until the dog became anorexic, obtunded and exhibited circling to the left. At necropsy examination, a mass was detected in the left forebrain, impinging on the cribriform plate. Microscopically, the mass was composed of sheets of round to pleomorphic neoplastic cells with vacuolated cytoplasm. Nuclear atypia, anisocytosis and anisokaryosis were common. Numerous bizarre, multinucleated giant cells containing 60 or more nuclei and giant mononuclear cells were present. The matrix contained abundant reticulin. Immunohistochemistry revealed the neoplastic cells uniformly to express vimentin, and a small number of neoplastic cells expressed glial fibrillary acid protein. A diagnosis of giant cell glioblastoma was made. Although well recognized in man, this tumour has been documented rarely in the veterinary literature.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology

UniBE Contributor:

Aloisio, Fabio

ISSN:

0021-9975

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:31

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1016/j.jcpa.2010.10.008

Web of Science ID:

000290068800012

URI:

https://boris.unibe.ch/id/eprint/12003 (FactScience: 218273)

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