Ivanyuk, Anton; García Segarra, Nuria; Buclin, Thierry; Klein, Andrea; Jacquier, David; Newman, Christopher J; Blötzer, Clemens Florian (2018). Myoglobinuria in two patients with Duchenne muscular dystrophy after treatment with zoledronate: a case-report and call for caution. Neuromuscular disorders, 28(10), pp. 865-867. Elsevier 10.1016/j.nmd.2018.08.004
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Rhabdomyolysis with myoglobinuria is a recognized complication of dystrophinopathies. It can be triggered by infections, exercise or volatile anesthetics. To our knowledge, it has never been reported in boys with Duchenne muscular dystrophy (DMD) after the administration of bisphosphonates. We report two patients with DMD who presented an apparent transient rhabdomyolysis with myoglobinuria after zoledronate administration. Possible mechanisms could involve hypophosphatemia, a known dose-dependent side effect of bisphosphonates, and/or direct myotoxicity of biphosphonates. Physicians and families should be aware of rhabdomyolysis with myoglobinuria as a potential uncommon side effect of bisphosphonates in DMD, in particular of zoledronate.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Klein, Andrea Katharina, Blötzer, Clemens Florian |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0960-8966 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
20 Sep 2018 14:48 |
Last Modified: |
21 Dec 2022 18:37 |
Publisher DOI: |
10.1016/j.nmd.2018.08.004 |
PubMed ID: |
30217487 |
Uncontrolled Keywords: |
Duchenne muscular dystrophy bisphosphonates myoglobinuria zoledronate |
BORIS DOI: |
10.7892/boris.120038 |
URI: |
https://boris.unibe.ch/id/eprint/120038 |
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