Myoglobinuria in two patients with Duchenne muscular dystrophy after treatment with zoledronate: a case-report and call for caution.

Ivanyuk, Anton; García Segarra, Nuria; Buclin, Thierry; Klein, Andrea; Jacquier, David; Newman, Christopher J; Blötzer, Clemens (2018). Myoglobinuria in two patients with Duchenne muscular dystrophy after treatment with zoledronate: a case-report and call for caution. Neuromuscular disorders, 28(10), pp. 865-867. Elsevier 10.1016/j.nmd.2018.08.004

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Rhabdomyolysis with myoglobinuria is a recognized complication of dystrophinopathies. It can be triggered by infections, exercise or volatile anesthetics. To our knowledge, it has never been reported in boys with Duchenne muscular dystrophy (DMD) after the administration of bisphosphonates. We report two patients with DMD who presented an apparent transient rhabdomyolysis with myoglobinuria after zoledronate administration. Possible mechanisms could involve hypophosphatemia, a known dose-dependent side effect of bisphosphonates, and/or direct myotoxicity of biphosphonates. Physicians and families should be aware of rhabdomyolysis with myoglobinuria as a potential uncommon side effect of bisphosphonates in DMD, in particular of zoledronate.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Klein, Andrea and Blötzer, Clemens Florian

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0960-8966

Publisher:

Elsevier

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

20 Sep 2018 14:48

Last Modified:

08 Oct 2018 01:32

Publisher DOI:

10.1016/j.nmd.2018.08.004

PubMed ID:

30217487

Uncontrolled Keywords:

Duchenne muscular dystrophy bisphosphonates myoglobinuria zoledronate

BORIS DOI:

10.7892/boris.120038

URI:

https://boris.unibe.ch/id/eprint/120038

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