Absorbable mineral nanocomposite for biomedical applications: Influence of homogenous fiber dispersity on mechanical properties

Mulky, Elias; Maniura-Weber, Katharina; Frenz, Martin; Fortunato, Giuseppino; Luginbühl, Reto (2017). Absorbable mineral nanocomposite for biomedical applications: Influence of homogenous fiber dispersity on mechanical properties. Journal of biomedical materials research. Part A, 106(3), pp. 850-857. John Wiley & Sons 10.1002/jbm.a.36284

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Electrospun micro‐ and nanosized fibers are frequently used as reinforcing elements in low temperature ceramic composites for biomedical applications. Electrospinning of fibers yield, however, not individual fibers, but rather fiber‐mats that are difficult to separate. Most investigations have been performed on diced mats and highly nonhomogenous composites. We examined the influence of dispersed electrospun single micro‐ and nanometer fibers on the mechanical properties of calcium phosphate cement composites. Absorbable poly‐l‐lactic‐acid was electrospun yielding fibers with diameters of 244 ± 78 nm, named nanofibers (NF), and 1.0 ± 0.3 μm, named microfibers (MF). These fibers were cut using a particle assisted ultrasonication process and dispersed with hydroxyapatite nanoparticles and composites of low (5%) and high (30%) NF/MF content were engineered. The homogeneity of the fiber distribution was investigated by analyzing fracture areas regarding the number of fibers and Voronoi area size distribution. Variation of fiber distribution was significantly lower in the NF group as compared to the MF group. For composites containing 5% NF (V/V), an eightfold increase in the compressive fracture strength, and for the 30% NF (V/V) a threefold increase compared was measured. The composite containing 5% NF was identified as optimal regarding fiber distribution and strength. Our new method of engineering these composites allows for high volume fractions of NF with low variation in fiber distribution to be incorporated into composites, and shows the importance of using single filaments as reinforcing agents.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
08 Faculty of Science > Institute of Applied Physics

UniBE Contributor:

Frenz, Martin and Luginbühl, Reto

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

1549-3296

Publisher:

John Wiley & Sons

Language:

English

Submitter:

Franziska Stämpfli

Date Deposited:

24 Sep 2018 09:30

Last Modified:

23 Oct 2019 16:34

Publisher DOI:

10.1002/jbm.a.36284

PubMed ID:

29094503

BORIS DOI:

10.7892/boris.120072

URI:

https://boris.unibe.ch/id/eprint/120072

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