Radiosurgery of vestibular schwannoma: prognostic factors for hearing outcome using 3D-constructive interference in steady state (3D-CISS).

Wagner, Franca; Gandalini, Matteo; Hakim, Arsany; Ermis, Ekin; Leiser, Dominic; Zbinden, Martin; Anschütz, Lukas Peter; Raabe, Andreas; Caversaccio, Marco; Wiest, Roland; Herrmann, Evelyn (2018). Radiosurgery of vestibular schwannoma: prognostic factors for hearing outcome using 3D-constructive interference in steady state (3D-CISS). Strahlentherapie und Onkologie, 194(12), pp. 1132-1143. Springer 10.1007/s00066-018-1361-8

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PURPOSE Stereotactic radiosurgery (SRS) is an effective treatment for vestibular schwannoma (VS). Three-dimensional (3D) constructive interference in steady state (CISS) is the preferred magnetic resonance imaging (MRI) sequence for evaluating signal changes in the inner ear endolymph. Previous studies demonstrated a correlation between pretreatment cochlear signal intensity in 3D-CISS and posttherapeutic hearing outcomes. The purpose of our study was to compare 3D-CISS sequences before and after primary SRS of unilateral VSs to evaluate the effect of radiosurgery on the 3D-CISS signal intensities of cochlea and sacculus/utriculus. METHODS We retrospectively reviewed 47 patients with unilateral VS treated with SRS. The neuroradiological MRI datasets were analysed to evaluate the signal intensity of the inner ear structure, tumour size, Koos grade, tumour volume, and infiltration of the cochlear aperture before therapy and at follow-up. The differences in these signal intensities before SRS and at follow-up were correlated with clinical symptoms, cochlear radiation dose, tumour volume and infiltration of the cochlear aperture. RESULTS No differences were found between signal intensities in cochlea and utriculus/sacculus before and after SRS and no correlation with clinical symptoms, cochlear radiation dose, tumour volume, Koos grade or infiltration of the cochlear aperture (all p > 0.05). CONCLUSION Our study supports the theory of a complex interaction causing alteration of the endolymph protein concentration and not a direct dependency on the SRS. Use of modern dosing schemes will have a positive impact on clinical outcome with preservation of hearing in patients with VS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Wagner, Franca; Hakim, Arsany; Ermis, Ekin; Leiser, Dominic; Zbinden, Martin; Anschütz, Lukas Peter; Raabe, Andreas; Caversaccio, Marco; Wiest, Roland and Herrmann, Evelyn

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-099X

Publisher:

Springer

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

24 Sep 2018 11:32

Last Modified:

29 Nov 2018 01:32

Publisher DOI:

10.1007/s00066-018-1361-8

PubMed ID:

30203112

Uncontrolled Keywords:

3D-CISS Labyrinth signal loss Magnetic resonance imaging Radiosurgery Vestibular schwannoma

BORIS DOI:

10.7892/boris.120087

URI:

https://boris.unibe.ch/id/eprint/120087

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