Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma.

Pfeiffer, Christian; Nguissi, Nathalie Ata Nguepnjo; Chytiris, Magali; Bidlingmeyer, Phanie; Hänggi, Matthias; Kurmann, Rebekka; Zubler, Frédéric; Accolla, Ettore; Viceic, Dragana; Rusca, Marco; Oddo, Mauro; Rossetti, Andrea O; De Lucia, Marzia (2018). Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma. Annals of Clinical and Translational Neurology, 5(9), pp. 1016-1024. Wiley 10.1002/acn3.600

[img]
Preview
Text
2018 - Pfeiffer - ACN - PMID 30250859.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (247kB) | Preview

Objective Prominent research in patients with disorders of consciousness investigated the electrophysiological correlates of auditory deviance detection as a marker of consciousness recovery. Here, we extend previous studies by investigating whether somatosensory deviance detection provides an added value for outcome prediction in postanoxic comatose patients. Methods Electroencephalography responses to frequent and rare stimuli were obtained from 66 patients on the first and second day after coma onset. Results Multivariate decoding analysis revealed an above chance-level auditory discrimination in 25 patients on the first day and in 31 patients on the second day. Tactile discrimination was significant in 16 patients on the first day and in 23 patients on the second day. Single-day sensory discrimination was unrelated to patients' outcome in both modalities. However, improvement of auditory discrimination from first to the second day was predictive of good outcome with a positive predictive power (PPV) of 0.73 (CI = 0.52-0.88). Analyses considering the improvement of tactile, auditory and tactile, or either auditory or tactile discrimination showed no significant prediction of good outcome (PPVs = 0.58-0.68). Interpretation Our results show that in the acute phase of coma deviance detection is largely preserved for both auditory and tactile modalities. However, we found no evidence for an added value of somatosensory to auditory deviance detection function for coma-outcome prediction.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Hänggi, Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2328-9503

Publisher:

Wiley

Language:

English

Submitter:

Mirella Aeberhard

Date Deposited:

27 Sep 2018 16:18

Last Modified:

27 Sep 2018 16:18

Publisher DOI:

10.1002/acn3.600

PubMed ID:

30250859

BORIS DOI:

10.7892/boris.120143

URI:

https://boris.unibe.ch/id/eprint/120143

Actions (login required)

Edit item Edit item
Provide Feedback