Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review.

Goossens, N; de Vito, C; Mangia, A; Clément, S; Cenderello, G; Barrera, F; D'Ambrosio, R; Coppola, N; Zampino, R; Stanzione, M; Adinolfi, L E; Wedemeyer, H; Semmo, Nasser; Müllhaupt, B; Semela, D; Malinverni, R; Moradpour, D; Heim, M; Trincucci, G; Rubbia-Brandt, L; ... (2018). Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review. Journal of viral hepatitis, 25(8), pp. 920-929. Blackwell Science 10.1111/jvh.12891

[img] Text
Goossens_et_al-2018-Journal_of_Viral_Hepatitis.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (562kB) | Request a copy

It remains unclear whether hepatitis B virus (HBV) infection may modify the severity of viral steatosis in patients coinfected with chronic hepatitis C virus (HCV). We examined the influence of coinfection with HBV on prevalence of steatosis in chronic hepatitis C in a multi-centre cohort of HBV-HCV subjects, and by performing a systematic review and meta-analysis of the literature. We centrally and blindly assessed steatosis prevalence and severity in a cohort of HBV-HCV coinfected subjects compared to HCV and HBV monoinfected controls and we performed a systematic review of studies addressing the prevalence of steatosis in HBV-HCV subjects compared to HCV controls. In the clinical cohort, we included 85 HBV-HCV, 69 HBV and 112 HCV subjects from 16 international centres. There was no significant difference in steatosis prevalence between the HBV-HCV and the HCV groups (33% vs 45%, P = .11). In subgroup analysis, lean HBV-HCV subjects with detectable HBV DNA had less steatosis than lean HCV subjects matched for HCV viremia (15% vs 45%, P = .02). Our literature search identified 5 additional studies included in a systematic review. Overall, prevalence of steatosis > 5% was similar in HBV-HCV infection compared to HCV (pooled odds ratio [OR] 0.91, 95% CI 0.53-1.6) although there was significant heterogeneity (I 69%, P = .007). In conclusion, although the prevalence of steatosis is similar in HBV-HCV compared to HCV subjects, our analysis suggests that there may be an inhibitory effect of HCV-induced steatogenesis by HBV in certain subgroups of patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Semmo, Nasser

Subjects:

600 Technology
600 Technology > 610 Medicine & health

ISSN:

1352-0504

Publisher:

Blackwell Science

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

01 Oct 2018 11:03

Last Modified:

01 Oct 2018 11:03

Publisher DOI:

10.1111/jvh.12891

PubMed ID:

29532619

Uncontrolled Keywords:

hepatitis C virus hepatitis C-hepatitis B coinfection metabolic syndrome steatosis

BORIS DOI:

10.7892/boris.120176

URI:

https://boris.unibe.ch/id/eprint/120176

Actions (login required)

Edit item Edit item
Provide Feedback