Genetic alterations crossing the borders of distinct hematopoetic lineages and solid tumors: Diagnostic challenges in the era of high-throughput sequencing in hemato-oncology.

Shumilov, Evgenii; Flach, Johanna; Pabst Müller, Thomas Niklaus; Fiedler, Georg Martin; Angelillo, Anne; Trümper, Lorenz; Joncourt, Raphael; Kohlmann, Alexander; Bacher, Vera Ulrike (2018). Genetic alterations crossing the borders of distinct hematopoetic lineages and solid tumors: Diagnostic challenges in the era of high-throughput sequencing in hemato-oncology. Critical reviews in oncology, hematology, 126, pp. 64-79. Elsevier 10.1016/j.critrevonc.2018.03.020

[img] Text
AAS_Genetic alterations crossing the borders of distinct.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (968kB) | Request a copy

Owing to the introduction of next-generation sequencing (NGS) new challenges for diagnostic algorithms and the interpretation of the results for therapeutic decision making in hemato-oncology have arisen. Recurrent somatic mutations crossing the borders between different hematological entities and solid neoplasms have been detected. In analogy to mutant TP53, the same mutation type may occur in myeloid, B- or T-lymphatic malignancies or solid neoplasms. At the same time, a certain mutation can show different prognostic outcomes in different entities and co-existence of certain mutations may change the prognostic relevance. These insights may spark the investigation of targeted therapies with the same substances across different disease entities. This review article summarizes mutations that can emerge in different hematologic and solid malignancies and summarizes other obstacles in the era of modern molecular diagnostics, such as the phenomenon of "clonal hematopoiesis of indeterminate potential" being difficult to interpret in the individual patient.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Pabst Müller, Thomas Niklaus; Fiedler, Georg Martin; Angelillo, Anne; Joncourt, Raphael and Bacher, Vera Ulrike

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1040-8428

Publisher:

Elsevier

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

04 Oct 2018 09:36

Last Modified:

17 Jan 2019 11:12

Publisher DOI:

10.1016/j.critrevonc.2018.03.020

PubMed ID:

29759569

Uncontrolled Keywords:

Clonal hematopoiesis of indeterminate potential (CHIP) Lineage crossover Modern molecular genetic era Next-generation sequencing (NGS) Recurrent somatic mutations

BORIS DOI:

10.7892/boris.120292

URI:

https://boris.unibe.ch/id/eprint/120292

Actions (login required)

Edit item Edit item
Provide Feedback