Should Sarcopenia Increase Priority for Transplant or Is It a Contraindication?

Stirnimann, Guido; Ebadi, Maryam; Tandon, Puneeta; Montano-Loza, Aldo J (2018). Should Sarcopenia Increase Priority for Transplant or Is It a Contraindication? Current gastroenterology reports, 20(11), p. 50. Springer 10.1007/s11894-018-0656-3

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PURPOSE OF REVIEW The purpose of this review is to discuss the current evidence regarding the impact of sarcopenia on patients with cirrhosis awaiting liver transplantation and to determine if its presence should be considered a criterion for expedited transplantation or a contraindication for transplantation. RECENT FINDINGS Sarcopenia is a negative predictor of survival in patients on a waiting list and after liver transplant. The gut-liver axis and the liver-muscle axis have been explored to understand the complex pathophysiology of sarcopenia. Sarcopenia is a frequent finding in patients with cirrhosis. The diagnosis is ideally based on cross-sectional image analysis (CT or MRI) and treatment consists of optimization of caloric and protein intake. To date, prioritizing tools for liver transplantation have not included nutrition or sarcopenia parameters. Patients with a low Model for End-Stage Liver Disease (MELD) or MELD-Na score and sarcopenia would benefit from prioritization for transplant in order to reduce time on waiting list and therefore mortality.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Stirnimann, Guido

Subjects:

600 Technology
600 Technology > 610 Medicine & health

ISSN:

1534-312X

Publisher:

Springer

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

11 Dec 2018 14:33

Last Modified:

23 Oct 2019 12:35

Publisher DOI:

10.1007/s11894-018-0656-3

PubMed ID:

30259203

Uncontrolled Keywords:

Cirrhosis End-stage liver disease Liver transplantation Low muscle mass Sarcopenia

BORIS DOI:

10.7892/boris.120316

URI:

https://boris.unibe.ch/id/eprint/120316

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