Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging.

Yu, Siqing; Früh Epstein, Beatrice; Steinmair, Dagmar; Ebneter, Andreas; Wolf, Sebastian; Zinkernagel, Martin; Munk, Marion (2018). Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging. PLoS ONE, 13(10), e0204501. Public Library of Science 10.1371/journal.pone.0204501

[img]
Preview
Text
journal.pone.0204501.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (2MB) | Preview

PURPOSE To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). METHODS Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 × 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel continuity, vessel visibility and presence of artefacts were evaluated by two blinded graders using a predefined grading protocol. RESULTS Thirteen eyes of 12 patients met the inclusion criteria. There was a significant increase of perfusion and vessel densities in both the SCP and the DCP after cataract surgery within the 3 × 3 mm images. Significantly better distinguishability of FAZ border was observed postoperatively in both SCP and DCP, however, FAZ area and perimeter measurements did not significantly change after cataract surgery. Mean number of motion artifacts in SCP and DCP numerically decreased by 37% (P = .089) and 42% (P = .080). CONCLUSIONS Lens opacities have a significant influence on retinal blood flow measurements in SS-OCTA and should be considered in quantitative vessel analysis. Inflammation may also impact the assessment of density parameters. FAZ measurements seems to be the most robust parameters in terms of media opacity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde

UniBE Contributor:

Yu, Siqing; Früh Epstein, Beatrice; Steinmair, Dagmar; Ebneter, Andreas; Wolf, Sebastian; Zinkernagel, Martin and Munk, Marion

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Marion Munk

Date Deposited:

05 Oct 2018 09:41

Last Modified:

23 Oct 2019 04:50

Publisher DOI:

10.1371/journal.pone.0204501

PubMed ID:

30278057

BORIS DOI:

10.7892/boris.120337

URI:

https://boris.unibe.ch/id/eprint/120337

Actions (login required)

Edit item Edit item
Provide Feedback