Accuracy of different three-dimensional subcortical human brain atlases for DBS -lead localisation.

Nowacki, Andreas; Nguyen, T A-K; Tinkhauser, Gerd; Petermann, Katrin; Debove, Ines; Wiest, Roland; Pollo, Claudio (2018). Accuracy of different three-dimensional subcortical human brain atlases for DBS -lead localisation. NeuroImage: Clinical, 20, pp. 868-874. Elsevier 10.1016/j.nicl.2018.09.030

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BACKGROUND Accurate interindividual comparability of deep brain stimulation (DBS) lead locations in relation to the surrounding anatomical structures is of eminent importance to define and understand effective stimulation areas. The objective of the current work is to compare the accuracy of the DBS lead localisation relative to the STN in native space with four recently developed three-dimensional subcortical brain atlases in the MNI template space. Accuracy is reviewed by anatomical and volumetric analysis as well as intraoperative electrophysiological data. METHODS Postoperative lead localisations of 10 patients (19 hemispheres) were analysed in each individual patient based on Brainlab software (native space) and after normalization into the MNI space and application of 4 different human brain atlases using Lead-DBS toolbox within Matlab (template space). Each patient's STN was manually segmented and the relation between the reconstructed lead and the STN was compared to the 4 atlas-based STN models by applying the Dice coefficient. The length of intraoperative electrophysiological STN activity along different microelectrode recording tracks was measured and compared to reconstructions in native and template space. Descriptive non-parametric statistical tests were used to calculate differences between the 4 different atlases. RESULTS The mean STN volume of the study cohort was 153.3 ± 40.3 mm3 (n = 19). This is similar to the STN volume of the DISTAL atlas (166 mm3; p = .22), but significantly larger compared to the other atlases tested in this study. The anatomical overlap of the lead-STN-reconstruction was highest for the DISTAL atlas (0.56 ± 0.18) and lowest for the PD25 atlas (0.34 ± 0.17). A total number of 47 MER trajectories through the STN were analysed. There was a statistically significant discrepancy of the electrophysiogical STN activity compared to the reconstructed STN of all four atlases (p < .0001). CONCLUSION Lead reconstruction after normalization into the MNI template space and application of four different atlases led to different results in terms of the DBS lead position relative to the STN. Based on electrophysiological and imaging data, the DISTAL atlas led to the most accurate display of the reconstructed DBS lead relative to the DISTAL-based STN.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Nowacki, Andreas; Tinkhauser, Gerd; Petermann, Katrin; Debove, Ines; Wiest, Roland and Pollo, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2213-1582

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

08 Oct 2018 07:59

Last Modified:

28 Nov 2018 01:32

Publisher DOI:

10.1016/j.nicl.2018.09.030

PubMed ID:

30282063

Uncontrolled Keywords:

Deep brain stimulation Human brain atlas Lead localisation MNI space

BORIS DOI:

10.7892/boris.120351

URI:

https://boris.unibe.ch/id/eprint/120351

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