Age at natural menopause and life expectancy with and without type 2 diabetes.

Asllanaj, Eralda; Bano, Arjola; Glisic, Marija; Jaspers, Loes; Ikram, Mohammad Arfan; Laven, Joop S E; Vőlzke, Henry; Muka, Taulant; Franco, Oscar H (2019). Age at natural menopause and life expectancy with and without type 2 diabetes. Menopause - the journal of the North American Menopause Society, 26(4), pp. 387-394. Lippincott Williams & Wilkins 10.1097/GME.0000000000001246

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OBJECTIVE Effective interventions of future health care require a better understanding of the health risks associated with early onset of menopause and diabetes, but the necessary data are scarce. Little quantitative information is available about the combined association of early menopause and diabetes on life expectancy and the number of years lived with and without diabetes. METHODS We included 3,650 postmenopausal women aged 45+ years from the Rotterdam Study, a prospective population-based cohort study. Age at menopause categories were defined as follows: early (≤44 y old), normal (45-54 y old), and late (≥55 y old). For life table calculations, we used prevalence, incidence rates, and hazard ratios for three transitions (free of diabetes to diabetes, free of diabetes to death, and diabetes to death) stratifying by age at menopause categories and adjusting for confounders. RESULTS Compared with late menopause, the difference in life expectancy for women who experienced early menopause was -3.5 (95% CI, -6.6 to -0.8) years overall and -4.6 (95% CI, -8.9 to -0.9) years without diabetes. Compared with age at normal menopause, the difference in life expectancy for women who experienced early menopause was -3.1 (95% CI, -5.1 to -1.1) years overall and -3.3 (95% CI, -6.0 to -0.6) years without diabetes. CONCLUSIONS Women who experienced early menopause lived less long and spent fewer years without diabetes than women who experienced normal or late menopause.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Franco Duran, Oscar Horacio

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1072-3714

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

24 Oct 2018 15:03

Last Modified:

08 Nov 2019 22:34

Publisher DOI:

10.1097/GME.0000000000001246

PubMed ID:

30300301

BORIS DOI:

10.7892/boris.120533

URI:

https://boris.unibe.ch/id/eprint/120533

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