Pieper, K.; Schuster, T.; Levionnois, O.; Matis, U.; Bergadano, A. (2011). Antinociceptive efficacy and plasma concentrations of transdermal buprenorphine in dogs. Veterinary journal, 187(3), pp. 335-41. Amsterdam: Elsevier 10.1016/j.tvjl.2010.01.013
Full text not available from this repository. (Request a copy)To assess the antinociceptive efficacy of transdermal (TD) buprenorphine (B) in dogs, a prospective, positive-controlled experimental study was performed in 10 healthy Beagles. In an open label crossover design, the dogs initially received intravenous B (IVB, 0.02 mg kg(-1)) as a positive control, followed by TDB (52.5 mug h(-1)) 4 months later. Blood was collected at regular intervals for determination of the plasma concentrations of B ([B]) and its metabolite norbuprenorphine. The antinociceptive efficacy was assessed using thermal and mechanical models of nociception. The peak concentration [B] was 1.54 ng mL(-1) (+/-1.98) 60 h after TDB application, although three dogs had no measurable [B] after TDB. Maximum thermal threshold (TT) was 52.6 degrees C (+/-0.48) at 1h after IVB administration and 51.63 degrees C (+/-1.01) 72 h after TDB application. The significant increase in TT indicated that effective antinociception was achieved beyond 36 h after the application of TDB, lasting until patch removal. There was hysteresis between [B] and the antinociceptive effect.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) |
UniBE Contributor: |
Levionnois, Olivier, Bergadano, Alessandra |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1090-0233 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:31 |
Last Modified: |
17 Apr 2024 16:42 |
Publisher DOI: |
10.1016/j.tvjl.2010.01.013 |
Web of Science ID: |
000288921700012 |
URI: |
https://boris.unibe.ch/id/eprint/12055 (FactScience: 218331) |
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