Electrocardiographic predictors of mortality in patients after percutaneous coronary interventions - a nested case-control study.

Li, Jin; Wyrsch, Dominic; Heg, Dik; Stoller, Michael; Zanchin, Thomas; Perrin, Tilman; Windecker, Stephan; Räber, Lorenz; Roten, Laurent (2019). Electrocardiographic predictors of mortality in patients after percutaneous coronary interventions - a nested case-control study. Acta cardiologica, 74(4), pp. 341-349. Peeters 10.1080/00015385.2018.1494117

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BACKGROUND The outcome of patients undergoing percutaneous coronary interventions (PCIs) varies considerably. Several ECG parameters have recently emerged (PQ interval, P-wave, T-peak-to-T-end interval, T-wave, T/R ratio, J-wave) beyond traditional markers (rhythm, QRS, Q-wave, QT interval, ST segment) and were attributed important prognostic value in the setting of coronary artery disease. The present study integrated for the first time these ECG parameters altogether with the aim to determine their role in predicting patients' outcome after a PCI. METHODS A total of 3342 patients were enrolled in the present study between 2009 and 2013. In a nested case-control design, 644 patients who died within a year post-PCI (cases) were matched 1:4 with patients alive at that particular date (controls). RESULTS Our data showed that only the presence of a longer QT interval (heart rate-corrected using Bazett formula) was associated with increased risk of death after adjusting for multiple clinical and angiographic risk factors (adjusted OR 1.07; 95%CI 1.01-1.12, p = .022). CONCLUSION Our study emphasises the prognostic importance of the QT interval in identifying patients at increased risk of death during the first year after PCI. Clinical Trial Registration - URL: https://www.clinicaltrials.gov . Unique identifier: NCT02241291.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Li, Jin; Heg, Dierik Hans; Stoller, Michael; Perrin, Tilman; Windecker, Stephan; Räber, Lorenz and Roten, Laurent

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0001-5385

Publisher:

Peeters

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

25 Oct 2018 12:22

Last Modified:

22 Oct 2019 21:38

Publisher DOI:

10.1080/00015385.2018.1494117

PubMed ID:

30328801

Uncontrolled Keywords:

Coronary artery disease QT interval electrocardiography mortality

BORIS DOI:

10.7892/boris.120649

URI:

https://boris.unibe.ch/id/eprint/120649

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