Short-Term Effects of Elastic Chest Wall Restriction on Pulmonary Function in Children with Cystic Fibrosis.

Roethlisberger, Katrin; Nyilas, Sylvia; Riedel, Thomas; Wolfensberger, Jeremy; Singer, Florian; Latzin, Philipp (2018). Short-Term Effects of Elastic Chest Wall Restriction on Pulmonary Function in Children with Cystic Fibrosis. Respiration, 96(6), pp. 535-542. Karger 10.1159/000491094

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BACKGROUND Elastic chest wall restriction introduced by Chevaillier is thought to reduce existing hyperinflation and improve mucus clearance from peripheral airways. In healthy adults, restriction decreases the functional residual capacity (FRC) and forced vital capacity (FVC), while ventilation inhomogeneity (lung clearance index [LCI]) increases. Pulmonary function response to restriction is unknown in individuals with cystic fibrosis (CF). OBJECTIVES To examine short-term effects of elastic chest wall restriction on pulmonary function in children with CF. METHODS Pulmonary function was first assessed twice 15 min apart at baseline and then again following 15 min of elastic chest wall restriction in 20 school-aged children with CF (12.3 ± 3.4 years). Primary outcomes were LCI from nitrogen multiple-breath washout, residual volume (RV), and FRC from plethysmography. Secondary outcomes were FVC and end-expiratory lung impedance (EELI) from electrical impedance tomography. Endpoints were test-retest reliability at baseline and lung function response to restriction, both on group and individual levels. RESULTS Test-retest reliability was excellent (intra-class correlation coefficients range 0.84-0.99). Following restriction, FRC significantly declined on average (95% CI) by -0.09 (-0.17 to -0.02) L. Similarly, FVC declined while LCI did not change. RV and EELI declined, but this did not reach statistical significance. On the individuals' level, heterogeneous changes in pulmonary function occurred following elastic chest wall restriction. CONCLUSIONS These findings indicate that the application of elastic chest wall restriction is safe, induces the intended decline in resting lung volume but does not systematically alter ventilation inhomogeneity in children with CF.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Nyilas, Sylvia Meryl; Riedel, Thomas; Singer, Florian and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0025-7931

Publisher:

Karger

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

09 Jan 2019 13:55

Last Modified:

24 Oct 2019 06:45

Publisher DOI:

10.1159/000491094

PubMed ID:

30130754

Uncontrolled Keywords:

Cystic fibrosis Physical therapy modalities Physiotherapy Pulmonary function test

BORIS DOI:

10.7892/boris.120755

URI:

https://boris.unibe.ch/id/eprint/120755

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