Response of cord blood cells to environmental, hereditary and perinatal factors: A prospective birth cohort study.

Lurà, Marco Patrick; Gorlanova, Olga; Müller, Loretta; Proietti, Elena; Vienneau, Danielle; Reppucci, Diana; Pavlovic, Rodoljub; Dahinden, Clemens; Röösli, Martin; Latzin, Philipp; Frey, Urs (2018). Response of cord blood cells to environmental, hereditary and perinatal factors: A prospective birth cohort study. PLoS ONE, 13(7), e0200236. Public Library of Science 10.1371/journal.pone.0200236

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BACKGROUND Many studies investigating the impact of individual risk factors on cord blood immune cell counts may be biased given that cord blood composition is influenced by a multitude of factors. The aim of this study was to comprehensively investigate the relative impact of environmental, hereditary and perinatal factors on cord blood cells. METHODS In 295 neonates from the prospective Basel-Bern Infant Lung Development Cohort, we performed complete blood counts and fluorescence-activated cell sorting scans of umbilical cord blood. The associations between risk factors and cord blood cells were assessed using multivariable linear regressions. RESULTS The multivariable regression analysis showed that an increase per 10μg/m3 of the average nitrogen dioxide 14 days before birth was associated with a decrease in leukocyte (6.7%, 95% CI:-12.1,-1.0) and monocyte counts (11.6%, 95% CI:-19.6,-2.8). Maternal smoking during pregnancy was associated with significantly lower cord blood cell counts in multiple cell populations. Moreover, we observed sex differences regarding eosinophilic granulocytes and plasmacytoid dendritic cells. Finally, significantly increased numbers of cord blood cells were observed in infants exposed to perinatal stress. Cesarean section seems to play a significant role in Th1/Th2 balance. CONCLUSIONS Our results suggest that all three: environmental, hereditary and perinatal factors play a significant role in the composition of cord blood cells at birth, and it is important to adjust for all of these factors in cord blood studies. In particular, perinatal circumstances seem to influence immune balance, which could have far reaching consequences in the development of immune mediated diseases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute for Immunology (discontinued)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Müller, Loretta Lina; Pavlovic, Rodoljub; Dahinden, Clemens A. and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

09 Jan 2019 12:26

Last Modified:

13 Jan 2019 02:37

Publisher DOI:

10.1371/journal.pone.0200236

PubMed ID:

29979752

BORIS DOI:

10.7892/boris.120757

URI:

https://boris.unibe.ch/id/eprint/120757

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