Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement.

Robinson, Paul D; Latzin, Philipp; Ramsey, Kathryn Angela; Stanojevic, Sanja; Aurora, Paul; Davis, Stephanie D; Gappa, Monika; Hall, Graham L; Horsley, Alex; Jensen, Renee; Lum, Sooky; Milla, Carlos; Nielsen, Kim G; Pittman, Jessica E; Rosenfeld, Margaret; Singer, Florian; Subbarao, Padmaja; Gustafsson, Per M; Ratjen, Felix (2018). Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement. American journal of respiratory and critical care medicine, 197(5), e1-e19. American Lung Association 10.1164/rccm.201801-0074ST

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BACKGROUND Obstructive airway disease is nonuniformly distributed throughout the bronchial tree, although the extent to which this occurs can vary among conditions. The multiple-breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The European Respiratory Society/American Thoracic Society inert gas washout consensus statement led to the emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently, the focus has shifted to MBW applications within preschool subjects (aged 2-6 yr), where a "window of opportunity" exists for early diagnosis of obstructive lung disease and intervention. METHODS This preschool-specific technical standards document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. RESULTS Recommendations were devised across areas that place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. CONCLUSIONS Consensus recommendations are outlined to direct interested groups of manufacturers, researchers, and clinicians in preschool device design, test performance, and data analysis for the MBW technique.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Latzin, Philipp; Ramsey, Kathryn Angela and Singer, Florian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1073-449X

Publisher:

American Lung Association

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

31 Jan 2019 12:05

Last Modified:

31 Jan 2019 12:05

Publisher DOI:

10.1164/rccm.201801-0074ST

PubMed ID:

29493315

Uncontrolled Keywords:

cystic fibrosis lung clearance index multiple-breath washout peripheral airway function

BORIS DOI:

10.7892/boris.120761

URI:

https://boris.unibe.ch/id/eprint/120761

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