Actinobaculum schaalii an emerging pediatric pathogen?

Zimmermann, Petra; Berlinger, Livia; Liniger, Benjamin; Grunt, Sebastian; Agyeman, Philipp; Ritz, Nicole (2012). Actinobaculum schaalii an emerging pediatric pathogen? BMC infectious diseases, 12, p. 201. London: BioMed Central 10.1186/1471-2334-12-201

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Background Actinobaculum schaalii was first described as a causative agent for human infection in 1997. Since then it has mainly been reported causing urinary tract infections (UTI) in elderly individuals with underlying urological diseases. Isolation and identification is challenging and often needs molecular techniques. A. schaalii is increasingly reported as a cause of infection in humans, however data in children is very limited. Case presentation We present the case of an 8-month-old Caucasian boy suffering from myelomeningocele and neurogenic bladder who presented with a UTI. An ultrasound of the urinary tract was unremarkable. Urinalysis and microscopy showed an elevated leukocyte esterase test, pyuria and a high number of bacteria. Empiric treatment with oral co-trimoxazole was started. Growth of small colonies of Gram-positive rods was observed after 48 h. Sequencing of the 16S rRNA gene confirmed an A. schaalii infection 9 days later. Treatment was changed to oral amoxicillin for 14 days. On follow-up urinalysis was normal and urine cultures were negative. Conclusions A.schaalii is an emerging pathogen in adults and children. Colonization and subsequent infection seem to be influenced by the age of the patient. In young children with high suspicion of UTI who use diapers or in children who have known abnormalities of their urogenital tract, infection with A. schaalii should be considered and empiric antimicrobial therapy chosen accordingly.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery

UniBE Contributor:

Zimmermann, Petra Sabine; Liniger, Benjamin; Grunt, Sebastian and Agyeman, Philipp

ISSN:

1471-2334

Publisher:

BioMed Central

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:31

Last Modified:

06 Dec 2014 21:58

Publisher DOI:

10.1186/1471-2334-12-201

PubMed ID:

22928807

Web of Science ID:

000309170700001

BORIS DOI:

10.7892/boris.12094

URI:

https://boris.unibe.ch/id/eprint/12094 (FactScience: 218375)

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