Bufonid herpesvirus 1 (BfHV1) associated dermatitis and mortality in free ranging common toads (Bufo bufo) in Switzerland.

Origgi, Francesco; Schmidt, Benedikt R; Lohmann, Petra; Otten, Patricia; Meier, Roman Kaspar; Pisano, Simone; Moore-Jones, Gaia Alessandra; Tecilla, Marco; Sattler, Ursula; Wahli, Thomas; Gaschen, Véronique; Stoffel, Michael Hubert (2018). Bufonid herpesvirus 1 (BfHV1) associated dermatitis and mortality in free ranging common toads (Bufo bufo) in Switzerland. Scientific Reports, 8(1), p. 14737. Nature Publishing Group 10.1038/s41598-018-32841-0

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Here we report the discovery and partial characterization of a novel herpesvirus tentatively named Bufonid herpesvirus 1 (BfHV1) from severe dermatitis in free ranging common toads (Bufo bufo) in Switzerland. The disease has been observed in toads every year since 2014, in spring, during the mating season, at different and distant locations. The virus is found in the skin and occasionally in the brain of infected toads. The genome of the virus is at least 158 Kb long and contains at least 152 open reading frames with a minimal length of 270 nt. The genome of BfHV1 contains all the signature genes that are present in alloherpesviruses. Phylogenetic analysis based on the amino acid sequence of the DNA polymerase and terminase proteins positions the novel virus among the members of the genus Batrachovirus, family Alloherpesviridae. This is the first herpesvirus ever characterized in common toads.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Anatomy
09 Interdisciplinary Units > Microscopy Imaging Center MIC
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Origgi, Francesco; Meier, Roman Kaspar; Pisano, Simone; Moore-Jones, Gaia Alessandra; Sattler, Ursula; Wahli, Thomas; Gaschen, Véronique and Stoffel, Michael Hubert

Subjects:

500 Science
600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Vanessa Alice Blum

Date Deposited:

14 Nov 2018 09:18

Last Modified:

10 Jan 2019 11:31

Publisher DOI:

10.1038/s41598-018-32841-0

PubMed ID:

30283010

BORIS DOI:

10.7892/boris.121193

URI:

https://boris.unibe.ch/id/eprint/121193

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