Impact of arterial injury on neointimal hyperplasia after implantation of drug-eluting stents in coronary arteries: an intravascular ultrasound study

Eshtehardi, Parham; Cook, Stéphane; Wandel, Simon; Räber, Lorenz; Wenaweser, Peter; Togni, Mario; Vogel, Rolf; Garachemani, Ali; Eberli, Franz R; Lüscher, Thomas F; Jüni, Peter; Hess, Otto M; Meier, Bernhard; Windecker, Stephan (2010). Impact of arterial injury on neointimal hyperplasia after implantation of drug-eluting stents in coronary arteries: an intravascular ultrasound study. EuroIntervention, 6(4), pp. 467-474. Toulouse: Europa Digital & Publishing 10.4244/EIJ30V6I4A7

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Aims: We investigated the impact of arterial injury on neointimal hyperplasia following implantation of drug-eluting stents (DES). Methods and results: A total of 196 patients with 223 segments (sirolimus-eluting stents [SES]: 104, paclitaxel-eluting stents [PES]: 119) underwent intravascular ultrasound eight months after DES implantation. Arterial injury was defined as the balloon-to-artery ratio (BAR). Segments were categorised into two groups: high BAR defined as BAR>1.1 (120 segments), and low BAR defined as BAR ≤1.1 (103 segments). Baseline clinical characteristics were similar for both groups. Although reference vessel diameter was smaller, stent diameter, maximal balloon pressure and balloon diameter were higher in the high BAR compared with the low BAR group. Lumen (7.10±1.91 vs. 6.25±1.69, p=0.001), stent (7.31±1.95 vs. 6.41±1.80, p=0.001), and external elastic membrane (17.1±4.9 vs. 14.8±4.0, p<0.0001) areas (mm2) were higher, but neointimal hyperplasia (0.21±0.36 vs. 0.16±0.48, p=0.42) area (mm2) was similar in the high BAR compared with the low BAR group. Arterial injury as assessed by BAR was not associated with the amount of neointimal hyperplasia (R2=0.003, p=0.40). Conclusions: Arterial injury does not correlate with the amount of neointimal hyperplasia following DES implantation. Conventionally aggressive DES implantation techniques do not adversely affect long-term outcome with respect to restenosis. - See more at: http://www.pcronline.com/eurointervention/30th_issue/79/#sthash.1do4X31G.dpuf

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Eshtehardi, Parham; Cook, Stéphane; Wandel, Simon; Räber, Lorenz; Wenaweser, Peter Martin; Togni, Mario; Vogel, Rolf; Jüni, Peter; Hess, Otto; Meier, Bernhard and Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1774-024X

Publisher:

Europa Digital & Publishing

Language:

English

Submitter:

Lorenz Räber

Date Deposited:

04 Oct 2013 14:09

Last Modified:

10 Dec 2015 16:08

Publisher DOI:

10.4244/EIJ30V6I4A7

PubMed ID:

20884434

Web of Science ID:

000294134900008

Uncontrolled Keywords:

Aged, Angioplasty, Balloon, Coronary, Animals, Coronary Angiography, Coronary Vessels, Drug-Eluting Stents, Female, Humans, Hyperplasia, Male, Middle Aged, Paclitaxel, Sirolimus, Tunica Intima, Ultrasonography, Interventional

BORIS DOI:

10.7892/boris.1212

URI:

https://boris.unibe.ch/id/eprint/1212 (FactScience: 202244)

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