Efficacy and acceptability of pharmacological interventions for the treatment of antipsychotic-related weight gain and metabolic abnormalities : a systematic review and network meta-analysis

Schoretsanitis, Georgios; Correll, Christoph U.; Gründer, Gerhard; Paulzen, Michael; Ntogka, Maria; Leucht, Stefan; Nikolakopoulou, Adriani (2018). Efficacy and acceptability of pharmacological interventions for the treatment of antipsychotic-related weight gain and metabolic abnormalities : a systematic review and network meta-analysis (Unpublished)

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Antipsychotic treatment (AP) is associated with metabolic abnormalities including weight gain. Targeting AP-associated weight gain, several pharmacological interventions have been investigated. Nevertheless, there is barely evidence for comparative efficacy and acceptability of these interventions. In this study, we will systematically review evidence for weight loss reducing agents in AP-medicated patients and compare outcomes of interventions in terms of efficacy and acceptability. Only blinded, randomized controlled studies of adjunctive agents for weight loss reduction in AP-medicated patients will be included. Pooled data will be analysed using a network meta-analysis. The primary outcomes will be measured as the mean difference for weight change and as odds ratio for treatment discontinuations due to any cause. Further analyses will encompass an additive model to evaluate the influence of components such as lifestyle counselling, exercise and diet. Subgroup, meta-regression and sensitivity analyses will focus on the impact of factors such as age, sex, body mass index, AP dose and type of AP. Results will be published in a peer-reviewed journal.

Item Type:

Working Paper

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Schoretsanitis, Georgios and Nikolakopoulou, Adriani

Subjects:

600 Technology > 610 Medicine & health

Language:

English

Submitter:

Georgios Schoretsanitis

Date Deposited:

22 Nov 2018 09:47

Last Modified:

22 Nov 2018 09:47

BORIS DOI:

10.7892/boris.121244

URI:

https://boris.unibe.ch/id/eprint/121244

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