Molecular footprints of muscle-invasive bladder cancer in smoking and nonsmoking patients.

Fantini, Damiano; Seiler, Roland; Meeks, Joshua J (2019). Molecular footprints of muscle-invasive bladder cancer in smoking and nonsmoking patients. Urologic oncology - seminars and original investigations, 37(11), pp. 818-825. Elsevier 10.1016/j.urolonc.2018.09.017

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BACKGROUND Bladder cancer is the fifth most common cancer in the United States and smoking is the largest known risk factor. Tobacco-derived carcinogens may induce the accumulation of somatic mutations in urothelial cells, and likely promote tumorigenesis. However, it is still unknown whether smoking-induced bladder carcinogenesis results in tumors with distinctive molecular features that can be therapeutically exploited. METHODS We investigated the genomic alterations of human bladder cancer and examined their association with patient smoking history. We performed bioinformatic analyses and looked at differences in gene expression, somatic mutations, and DNA mutational signatures comparing nonsmokers, reformed smokers, and current smokers. RESULTS We detected a limited set of gene expression and gene mutation differences between smokers and nonsmokers. We also identified a specific mutational signature that is enriched in tumors from smokers. This mutational signature was described before and has been linked to specific DNA repair defects in human bladder tumors, as well as to the direct effect of nitrosamine carcinogens in the BBN murine model of bladder cancer. CONCLUSION We showed associations between smoking status and selected mutational signatures, which could provide insights in the biology of bladder carcinogenesis and tumor progression.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Seiler, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1078-1439

Publisher:

Elsevier

Language:

English

Submitter:

Jeannine Wiemann

Date Deposited:

30 Nov 2018 08:05

Last Modified:

02 Nov 2019 01:30

Publisher DOI:

10.1016/j.urolonc.2018.09.017

PubMed ID:

30446446

Uncontrolled Keywords:

APOBEC mutagenesis BBN mouse model Bladder cancer Cancer genome Mutational signatures Smoking-related carcinogenesis

BORIS DOI:

10.7892/boris.121696

URI:

https://boris.unibe.ch/id/eprint/121696

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