Incidence of second primary cancers after radiotherapy combined with platinum and/or cetuximab in head and neck cancer patients.

Eliçin, Olgun; Sermaxhaj, Burim; Bojaxhiu, Beat; Shelan, Mohamed; Giger, Roland; Rauch, Daniel; Aebersold, Daniel (2019). Incidence of second primary cancers after radiotherapy combined with platinum and/or cetuximab in head and neck cancer patients. Strahlentherapie und Onkologie, 195(6), pp. 468-474. Springer 10.1007/s00066-018-1400-5

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PURPOSE The second primary cancer (SPC) incidence after treatment with platinum-based chemotherapy and cetuximab in combination with radiotherapy has not been previously reported. Our aim was to compare SPC risk following radiotherapy in combination with these agents for the treatment of head and neck squamous cell carcinoma (HNSCC). METHODS The charts of 296 cases treated for loco-regionally advanced HNSCC between 2009 and 2015 were retrospectively reviewed for patient, tumor, and procedural characteristics. All patients were planned to undergo radiotherapy either with platinum compounds (group: Platinum) or monoclonal antibody cetuximab (group: Cetuximab). A third group of patients switched from platinum compounds to cetuximab due to toxicity (group: Switch). Treatment groups were evaluated for the incidence of SPC with log-rank test. Possible confounders were investigated with multivariate Cox's proportional hazards model. All tests were two-sided, and a p < 0.05 was set to indicate statistical significance. RESULTS Median follow-up was 36 months. Platinum, Cetuximab, and Switch groups consisted of 158, 101, and 37 patients, respectively. Three-year overall survival in the whole cohort was 70%. The rate of SPC was comparable between Platinum (9.2%) and Cetuximab (11.5%) groups (p = 0.98), whereas the patients in the Switch group were exposed to a significantly higher incidence of SPC (23.3%) in 3 years (p = 0.01). The multivariate model indicated Switch to be the only variable correlating with an increased risk for SPC. CONCLUSIONS The Switch strategy may expose the patients to an increased risk of developing SPC. The use of switch should be advocated with caution until robust pre-clinical and clinical data are available.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Eliçin, Olgun; Sermaxhaj, Burim; Bojaxhiu, Beat; Shelan, Mohamed; Giger, Roland; Rauch, Daniel and Aebersold, Daniel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-099X

Publisher:

Springer

Language:

German

Submitter:

Beatrice Scheidegger

Date Deposited:

28 Nov 2018 14:10

Last Modified:

22 Oct 2019 20:11

Publisher DOI:

10.1007/s00066-018-1400-5

PubMed ID:

30465265

Uncontrolled Keywords:

Anti-epidermal growth factor receptor Carboplatin Cisplatin Radiation Secondary malignancies Squamous cell carcinoma

BORIS DOI:

10.7892/boris.121743

URI:

https://boris.unibe.ch/id/eprint/121743

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